Fitting a Direct Kernel PLS model on the (Deviance) Residuals

This function computes the Direct Kernel PLSR model with the Residuals of a Cox-Model fitted with an intercept as the only explanatory variable as the response and Xplan as explanatory variables. Default behaviour uses the Deviance residuals.

coxDKpls2DR(Xplan, ...)

# S3 method for default
coxDKpls2DR(
  Xplan,
  time,
  time2,
  event,
  type,
  origin,
  typeres = "deviance",
  collapse,
  weighted,
  scaleX = TRUE,
  scaleY = TRUE,
  ncomp = min(7, ncol(Xplan)),
  methodpls = "kernelpls",
  validation = "CV",
  plot = FALSE,
  allres = FALSE,
  kernel = "rbfdot",
  hyperkernel,
  verbose = TRUE,
  ...
)

# S3 method for formula
coxDKpls2DR(
  Xplan,
  time,
  time2,
  event,
  type,
  origin,
  typeres = "deviance",
  collapse,
  weighted,
  scaleX = TRUE,
  scaleY = TRUE,
  ncomp = min(7, ncol(Xplan)),
  methodpls = "kernelpls",
  validation = "CV",
  plot = FALSE,
  allres = FALSE,
  dataXplan = NULL,
  subset,
  weights,
  model_frame = FALSE,
  kernel = "rbfdot",
  hyperkernel,
  verbose = TRUE,
  model_matrix = FALSE,
  contrasts.arg,
  ...
)

Arguments

Xplan

a formula or a matrix with the eXplanatory variables (training) dataset

...

Arguments to be passed on to survival::coxph.

time

for right censored data, this is the follow up time. For interval data, the first argument is the starting time for the interval.

time2

The status indicator, normally 0=alive, 1=dead. Other choices are TRUE/FALSE (TRUE = death) or 1/2 (2=death). For interval censored data, the status indicator is 0=right censored, 1=event at time, 2=left censored, 3=interval censored. Although unusual, the event indicator can be omitted, in which case all subjects are assumed to have an event.

event

ending time of the interval for interval censored or counting process data only. Intervals are assumed to be open on the left and closed on the right, (start, end]. For counting process data, event indicates whether an event occurred at the end of the interval.

type

character string specifying the type of censoring. Possible values are "right", "left", "counting", "interval", or "interval2". The default is "right" or "counting" depending on whether the time2 argument is absent or present, respectively.

origin

for counting process data, the hazard function origin. This option was intended to be used in conjunction with a model containing time dependent strata in order to align the subjects properly when they cross over from one strata to another, but it has rarely proven useful.

typeres

character string indicating the type of residual desired. Possible values are "martingale", "deviance", "score", "schoenfeld", "dfbeta", "dfbetas", and "scaledsch". Only enough of the string to determine a unique match is required.

collapse

vector indicating which rows to collapse (sum) over. In time-dependent models more than one row data can pertain to a single individual. If there were 4 individuals represented by 3, 1, 2 and 4 rows of data respectively, then collapse=c(1,1,1,2,3,3,4,4,4,4) could be used to obtain per subject rather than per observation residuals.

weighted

if TRUE and the model was fit with case weights, then the weighted residuals are returned.

scaleX

Should the Xplan columns be standardized ?

scaleY

Should the time values be standardized ?

ncomp

The number of components to include in the model. The number of components to fit is specified with the argument ncomp. It this is not supplied, the maximal number of components is used (taking account of any cross-validation).

methodpls

The multivariate regression method to be used. See mvrCv for details.

validation

character. What kind of (internal) validation to use. If validation = "CV", cross-validation is performed. The number and type of cross-validation segments are specified with the arguments segments and segment.type. See mvrCv for details. If validation = "LOO", leave-one-out cross-validation is performed. It is an error to specify the segments when validation = "LOO" is specified.

plot

Should the survival function be plotted ?)

allres

FALSE to return only the Cox model and TRUE for additionnal results. See details. Defaults to FALSE.

kernel

the kernel function used in training and predicting. This parameter can be set to any function, of class kernel, which computes the inner product in feature space between two vector arguments (see kernels). The kernlab package provides the most popular kernel functions which can be used by setting the kernel parameter to the following strings:

list("rbfdot")

Radial Basis kernel "Gaussian"

list("polydot")

Polynomial kernel

list("vanilladot")

Linear kernel

list("tanhdot")

Hyperbolic tangent kernel

list("laplacedot")

Laplacian kernel

list("besseldot")

Bessel kernel

list("anovadot")

ANOVA RBF kernel

list("splinedot")

Spline kernel

hyperkernel

the list of hyper-parameters (kernel parameters). This is a list which contains the parameters to be used with the kernel function. For valid parameters for existing kernels are :

• sigma, inverse kernel width for the Radial Basis kernel function "rbfdot" and the Laplacian kernel "laplacedot".

• degree, scale, offset for the Polynomial kernel "polydot".

• scale, offset for the Hyperbolic tangent kernel function "tanhdot".

• sigma, order, degree for the Bessel kernel "besseldot".

• sigma, degree for the ANOVA kernel "anovadot".

In the case of a Radial Basis kernel function (Gaussian) or Laplacian kernel, if hyperkernel is missing, the heuristics in sigest are used to calculate a good sigma value from the data.

verbose

Should some details be displayed ?

dataXplan

an optional data frame, list or environment (or object coercible by as.data.frame to a data frame) containing the variables in the model. If not found in dataXplan, the variables are taken from environment(Xplan), typically the environment from which coxDKpls2DR is called.

subset

an optional vector specifying a subset of observations to be used in the fitting process.

weights

an optional vector of 'prior weights' to be used in the fitting process. Should be NULL or a numeric vector.

model_frame

If TRUE, the model frame is returned.

model_matrix

If TRUE, the model matrix is returned.

contrasts.arg

a list, whose entries are values (numeric matrices, functions or character strings naming functions) to be used as replacement values for the contrasts replacement function and whose names are the names of columns of data containing factors.

Value

If allres=FALSE :

cox_DKpls2DR

Final Cox-model.

If allres=TRUE :

tt_DKpls2DR

PLSR components.

cox_DKpls2DR

Final Cox-model.

DKpls2DR_mod

The PLSR model.

Details

If allres=FALSE returns only the final Cox-model. If allres=TRUE returns a list with the PLS components, the final Cox-model and the PLSR model. allres=TRUE is useful for evluating model prediction accuracy on a test sample.

References

plsRcox, Cox-Models in a high dimensional setting in R, Frederic Bertrand, Philippe Bastien, Nicolas Meyer and Myriam Maumy-Bertrand (2014). Proceedings of User2014!, Los Angeles, page 152.

Deviance residuals-based sparse PLS and sparse kernel PLS regression for censored data, Philippe Bastien, Frederic Bertrand, Nicolas Meyer and Myriam Maumy-Bertrand (2015), Bioinformatics, 31(3):397-404, doi:10.1093/bioinformatics/btu660.

See also

coxph, plsr

Author

Frédéric Bertrand
frederic.bertrand@utt.fr
http://www-irma.u-strasbg.fr/~fbertran/

Examples

data(micro.censure)
data(Xmicro.censure_compl_imp)

X_train_micro <- apply((as.matrix(Xmicro.censure_compl_imp)),FUN="as.numeric",MARGIN=2)[1:80,]
X_train_micro_df <- data.frame(X_train_micro)
Y_train_micro <- micro.censure$survyear[1:80]
C_train_micro <- micro.censure$DC[1:80]

(cox_DKpls2DR_fit=coxDKpls2DR(X_train_micro,Y_train_micro,C_train_micro,ncomp=6,validation="CV"))
#> Kernel :  rbfdot 
#> Estimated_sigma  0.01178044 
#> Call:
#> coxph(formula = YCsurv ~ ., data = tt_DKpls2DR)
#> 
#>             coef exp(coef)  se(coef)     z       p
#> Comp.1 2.872e+00 1.767e+01 1.102e+00 2.606 0.00916
#> Comp.2 7.802e+00 2.444e+03 2.519e+00 3.097 0.00196
#> Comp.3 5.216e+00 1.843e+02 1.811e+00 2.881 0.00397
#> Comp.4 1.519e+01 3.965e+06 4.972e+00 3.056 0.00224
#> Comp.5 3.670e+00 3.926e+01 1.994e+00 1.840 0.06572
#> Comp.6 1.042e+01 3.348e+04 4.092e+00 2.546 0.01089
#> 
#> Likelihood ratio test=65.31  on 6 df, p=3.727e-12
#> n= 80, number of events= 17 

#Fixing sigma to compare with pls2DR on Gram matrix; should be identical
(cox_DKpls2DR_fit=coxDKpls2DR(X_train_micro,Y_train_micro,C_train_micro,ncomp=6,
validation="CV",hyperkernel=list(sigma=0.01292786)))
#> Kernel :  rbfdot 
#> Used_sigma  0.01292786 
#> Call:
#> coxph(formula = YCsurv ~ ., data = tt_DKpls2DR)
#> 
#>             coef exp(coef)  se(coef)     z       p
#> Comp.1 3.014e+00 2.036e+01 1.148e+00 2.626 0.00864
#> Comp.2 8.946e+00 7.675e+03 2.874e+00 3.113 0.00185
#> Comp.3 6.488e+00 6.570e+02 2.289e+00 2.834 0.00460
#> Comp.4 1.746e+01 3.844e+07 5.722e+00 3.052 0.00227
#> Comp.5 4.090e+00 5.976e+01 2.119e+00 1.931 0.05354
#> Comp.6 1.096e+01 5.746e+04 4.048e+00 2.707 0.00678
#> 
#> Likelihood ratio test=69.03  on 6 df, p=6.472e-13
#> n= 80, number of events= 17 

X_train_micro_kern <- kernlab::kernelMatrix(kernlab::rbfdot(sigma=0.01292786),scale(X_train_micro))
(cox_DKpls2DR_fit2=coxpls2DR(~X_train_micro_kern,Y_train_micro,C_train_micro,ncomp=6,
validation="CV",scaleX=FALSE))
#> Error in model.matrix(mt0, mf0, , contrasts.arg = contrasts.arg): argument "contrasts.arg" is missing, with no default

(cox_DKpls2DR_fit=coxDKpls2DR(X_train_micro,Y_train_micro,C_train_micro,ncomp=6,
validation="CV",kernel="laplacedot",hyperkernel=list(sigma=0.01292786)))
#> Kernel :  laplacedot 
#> Used_sigma  0.01292786 
#> Call:
#> coxph(formula = YCsurv ~ ., data = tt_DKpls2DR)
#> 
#>              coef  exp(coef)   se(coef)     z      p
#> Comp.1  1.328e+02  4.670e+57  5.955e+01 2.230 0.0258
#> Comp.2  2.682e+02 3.000e+116  1.174e+02 2.284 0.0224
#> Comp.3  2.575e+02 7.031e+111  1.147e+02 2.246 0.0247
#> Comp.4  5.287e+02 4.007e+229  2.318e+02 2.281 0.0225
#> Comp.5  1.660e+02  1.198e+72  7.378e+01 2.250 0.0245
#> Comp.6  2.151e+02  2.503e+93  1.010e+02 2.130 0.0332
#> 
#> Likelihood ratio test=95.09  on 6 df, p=< 2.2e-16
#> n= 80, number of events= 17 

X_train_micro_kern <- kernlab::kernelMatrix(kernlab::laplacedot(sigma=0.01292786),
scale(X_train_micro))
(cox_DKpls2DR_fit2=coxpls2DR(~X_train_micro_kern,Y_train_micro,C_train_micro,ncomp=6,
validation="CV",scaleX=FALSE))
#> Error in model.matrix(mt0, mf0, , contrasts.arg = contrasts.arg): argument "contrasts.arg" is missing, with no default

(cox_DKpls2DR_fit=coxDKpls2DR(~X_train_micro,Y_train_micro,C_train_micro,ncomp=6,validation="CV"))
#> Error in model.matrix(mt0, mf0, , contrasts.arg = contrasts.arg): argument "contrasts.arg" is missing, with no default
(cox_DKpls2DR_fit=coxDKpls2DR(~.,Y_train_micro,C_train_micro,ncomp=6,validation="CV",
dataXplan=X_train_micro_df))
#> Error in model.matrix(mt0, mf0, , contrasts.arg = contrasts.arg): argument "contrasts.arg" is missing, with no default

(cox_DKpls2DR_fit=coxDKpls2DR(X_train_micro,Y_train_micro,C_train_micro,ncomp=6,
validation="CV",allres=TRUE))
#> Kernel :  rbfdot 
#> Estimated_sigma  0.01225667 
#> $tt_DKpls2DR
#>          Comp.1        Comp.2       Comp.3       Comp.4       Comp.5
#> 1  -0.055670703 -5.001190e-01 -0.199549167  0.086881495 -0.185311437
#> 2   0.096910973 -1.019416e-01  0.352115285 -0.278253325 -0.246492052
#> 3   0.292765559 -4.955896e-03  0.123426882 -0.018834364 -0.062395855
#> 4   0.026809951  4.190386e-02  0.064125583 -0.157142696 -0.005491528
#> 5   0.440991321 -7.693857e-02 -0.362689546  0.062262381 -0.145162116
#> 6  -0.130098939  7.208192e-02 -0.329291734 -0.224580834 -0.346308463
#> 7  -0.259629287  1.686702e-01 -0.165392286  0.075287156 -0.092086097
#> 8   0.547439571  1.946930e-01 -0.238652286  0.021254817  0.211672290
#> 9   0.036710441 -2.500111e-01  0.244933481 -0.107542270 -0.188056500
#> 10  0.109242258 -3.308583e-02  0.137282082 -0.181284029 -0.210400787
#> 11  0.208084326  2.434761e-01 -0.266806208  0.251554288  0.310731286
#> 12 -0.493963554  9.257084e-02 -0.192435506  0.245165333  0.277027785
#> 13  0.270996087 -2.999012e-01 -0.080194622 -0.118256139  0.240399808
#> 14 -0.349922772  1.936317e-01 -0.178839685 -0.202344621 -0.174577446
#> 15  0.139520596 -3.534579e-01  0.174421352  0.197080782  0.216153646
#> 16  0.328332542 -1.700691e-01 -0.158628526  0.109649758 -0.262931931
#> 17 -0.390109655 -2.705821e-02  0.038960270  0.008438613  0.167484761
#> 18 -0.281552878 -2.854530e-01 -0.031187866  0.142051134 -0.067298087
#> 19  0.015259720  7.097264e-02  0.139831078 -0.100503977  0.335933898
#> 20 -0.430788177  1.712268e-01 -0.170237734 -0.147407466 -0.059454612
#> 21 -0.113047866 -1.255776e-01  0.169974441  0.149083750 -0.368319059
#> 22  0.012393103 -2.397416e-01 -0.127242443  0.172919644 -0.032389738
#> 23  0.123384452 -3.614915e-02  0.243207536 -0.061170212  0.024905494
#> 24  0.129713666  2.920882e-01 -0.238669586 -0.120479086 -0.350981388
#> 25 -0.536014801 -1.191097e-01 -0.247958034  0.106701488 -0.049942797
#> 26 -0.436788814  2.635490e-01 -0.106709787 -0.086128284 -0.056167589
#> 27  0.363538760  2.163896e-03 -0.105815799 -0.071856013  0.049362889
#> 28  0.385694934 -4.995923e-02 -0.165823798  0.001383943 -0.232930495
#> 29 -0.300845850  1.883618e-01  0.339707556  0.020814032 -0.258572601
#> 30 -0.389738287  1.918516e-01 -0.108495489  0.003099092 -0.190029334
#> 31  0.277823309  8.941224e-02  0.337317375  0.343313488  0.006320499
#> 32 -0.332454565 -1.009426e-01 -0.020547452  0.058485773 -0.012948155
#> 33 -0.308827186 -2.380316e-01  0.412177402 -0.017518329 -0.065144140
#> 34 -0.159081933  1.520808e-01 -0.024009976 -0.152038328  0.397719157
#> 35  0.421648524 -2.755800e-02 -0.241222528  0.087073351  0.111323830
#> 36 -0.080578909 -1.870921e-02 -0.001923906 -0.024482296  0.360578327
#> 37  0.258308103  4.120398e-01 -0.024369458  0.170768707 -0.159060028
#> 38 -0.275793923  1.654762e-01  0.044945082  0.183113285 -0.149265309
#> 39 -0.440445120  1.328482e-01  0.086512048  0.050455102 -0.398844932
#> 40  0.145702482 -7.986301e-02  0.131651732  0.276386367 -0.245198975
#> 41 -0.120253121  1.058776e-01  0.228964942  0.017325781 -0.317536040
#> 42  0.453537697 -1.889206e-01 -0.242139618  0.060713369  0.047968413
#> 43 -0.468088129 -3.600261e-05  0.111080278  0.338627005  0.170607558
#> 44 -0.069700521 -2.837786e-02  0.217664982 -0.074614473 -0.634914194
#> 45 -0.324775792  1.691685e-01  0.106372446 -0.142610426 -0.024773453
#> 46  0.143132669  6.706875e-02 -0.537749970  0.025342030 -0.191186854
#> 47  0.004760992 -1.219538e-01 -0.125908008 -0.241473807 -0.316174061
#> 48  0.218265492 -1.919177e-02 -0.126409215 -0.346662583 -0.232504755
#> 49  0.420562179 -7.601560e-02 -0.207243741  0.071110421 -0.152208916
#> 50  0.047802841 -1.004434e-01  0.016697837 -0.062794749  0.354348820
#> 51 -0.132560113 -2.549378e-01  0.153025967 -0.017397908  0.378433781
#> 52  0.607565491 -1.752889e-01  0.189869726 -0.130513651 -0.178568949
#> 53  0.164179796 -2.226422e-01  0.314257258  0.034964269 -0.241974136
#> 54  0.144553816  4.838452e-01  0.408237829  0.079007111  0.066978529
#> 55  0.443572034  3.048235e-01  0.504102452  0.104879010 -0.052953574
#> 56 -0.288767115 -2.881719e-01  0.075509586  0.184390325  0.115870953
#> 57 -0.480642637 -2.967916e-01  0.075348470  0.105583409  0.217575385
#> 58 -0.196722093  3.880195e-01  0.308660751 -0.083917411  0.011293264
#> 59 -0.264049605  2.739597e-01 -0.284096805  0.099835754 -0.221765816
#> 60 -0.353218240  6.537290e-02 -0.156345286  0.059306814  0.265978466
#> 61  0.106200953  3.507324e-01 -0.068432532 -0.161131759  0.232214301
#> 62  0.196030322 -1.997288e-01  0.234026128 -0.025909388  0.420125254
#> 63  0.701483766  2.484298e-01  0.084391837  0.287300561  0.178293011
#> 64  0.340395875 -3.646363e-01 -0.096518053 -0.258402522 -0.164809478
#> 65  0.412528171  7.870374e-02  0.344458286 -0.103128504  0.176289352
#> 66 -0.071291399  6.385732e-02 -0.007974657 -0.182469003  0.247056546
#> 67 -0.371364162 -2.504757e-01 -0.292352861 -0.036722863  0.200722715
#> 68  0.048947534 -5.352239e-02 -0.113801846  0.151495111  0.117741457
#> 69  0.257922340  1.386482e-01  0.109346670 -0.001631214  0.335408719
#> 70 -0.193797764 -2.377655e-02 -0.100305492 -0.038321626  0.036502227
#> 71 -0.027919314  2.701561e-02 -0.031731163  0.216483402 -0.127465442
#> 72  0.066003239  3.264649e-01 -0.002165053  0.045874482  0.059520937
#> 73  0.258569511 -2.060115e-02  0.082834096 -0.253137433  0.300180181
#> 74 -0.219601438 -7.895998e-02 -0.050684000 -0.181170502  0.183408409
#> 75  0.413753255 -1.123860e-01 -0.030956330 -0.084493851  0.069561735
#> 76  0.409038122  9.525405e-02 -0.473435891  0.134590123 -0.001244937
#> 77 -0.233625422 -7.957008e-02  0.021701754 -0.274582612  0.319964973
#> 78 -0.139250099 -1.383748e-01 -0.018864399  0.022118250  0.186776939
#> 79 -0.378359315  1.543780e-01 -0.052524032 -0.254198144  0.316385319
#> 80 -0.390737272 -2.472824e-01  0.179191894  0.162935696 -0.244978855
#>          Comp.6
#> 1  -0.093508581
#> 2   0.069872997
#> 3  -0.155604310
#> 4  -0.096450060
#> 5  -0.073126560
#> 6   0.126675832
#> 7  -0.108981069
#> 8   0.090475256
#> 9  -0.030773481
#> 10 -0.017349793
#> 11  0.324469047
#> 12  0.052217390
#> 13  0.060678455
#> 14  0.001191161
#> 15 -0.122485022
#> 16  0.154495089
#> 17  0.208047010
#> 18  0.189656955
#> 19 -0.153112149
#> 20  0.060337972
#> 21 -0.023424012
#> 22  0.183943228
#> 23 -0.205921063
#> 24 -0.184267072
#> 25  0.041877352
#> 26  0.040527332
#> 27 -0.076091156
#> 28 -0.325217802
#> 29 -0.045631676
#> 30  0.044842383
#> 31  0.003873042
#> 32  0.048261294
#> 33 -0.026653031
#> 34 -0.017384089
#> 35  0.197668476
#> 36 -0.177943975
#> 37 -0.022594999
#> 38 -0.073933558
#> 39  0.148481563
#> 40 -0.085995735
#> 41 -0.125375202
#> 42 -0.185773436
#> 43  0.075374820
#> 44 -0.070161759
#> 45  0.248108283
#> 46 -0.034204065
#> 47 -0.012950866
#> 48  0.182376717
#> 49  0.046765763
#> 50 -0.014084170
#> 51 -0.032432404
#> 52  0.137233784
#> 53 -0.206946413
#> 54  0.157371498
#> 55  0.100105217
#> 56 -0.075368574
#> 57 -0.023452375
#> 58  0.147991659
#> 59 -0.118945122
#> 60 -0.239930007
#> 61 -0.253183849
#> 62 -0.021302130
#> 63  0.055606323
#> 64  0.205005166
#> 65  0.137666464
#> 66 -0.137622131
#> 67  0.021543898
#> 68  0.059474416
#> 69 -0.016183224
#> 70  0.049734865
#> 71 -0.199326629
#> 72 -0.117826795
#> 73  0.136200928
#> 74  0.071938698
#> 75  0.096340433
#> 76  0.038395862
#> 77 -0.123706326
#> 78 -0.021607028
#> 79 -0.042357643
#> 80  0.174362713
#> 
#> $cox_DKpls2DR
#> Call:
#> coxph(formula = YCsurv ~ ., data = tt_DKpls2DR)
#> 
#>             coef exp(coef)  se(coef)     z       p
#> Comp.1 2.905e+00 1.826e+01 1.113e+00 2.609 0.00908
#> Comp.2 8.232e+00 3.760e+03 2.645e+00 3.113 0.00185
#> Comp.3 5.687e+00 2.951e+02 1.981e+00 2.871 0.00409
#> Comp.4 1.612e+01 1.004e+07 5.267e+00 3.061 0.00221
#> Comp.5 3.837e+00 4.639e+01 2.043e+00 1.878 0.06033
#> Comp.6 1.068e+01 4.343e+04 4.067e+00 2.626 0.00864
#> 
#> Likelihood ratio test=66.85  on 6 df, p=1.807e-12
#> n= 80, number of events= 17 
#> 
#> $DKpls2DR_mod
#> Partial least squares regression , fitted with the kernel algorithm.
#> Cross-validated using 10 random segments.
#> Call:
#> plsr(formula = DR_coxph ~ ., ncomp = 6, data = new("kernelMatrix",     .Data = structure(c(1, 0.331027770430139, 0.441017481013547,     0.322633078445593, 0.530277608438971, 0.268430689504521,     0.402344669678313, 0.300825877430602, 0.511993824834656,     0.402557441283781, 0.353801173678485, 0.332106395724337,     0.299200186307347, 0.294440829033579, 0.510125491372311,     0.44618965342672, 0.273802958722685, 0.558299749502181, 0.332774677496374,     0.383935381267634, 0.47910542196087, 0.384619725441338, 0.305095615919302,     0.361274886738264, 0.352105886592268, 0.33567078205559, 0.231493507484785,     0.342548038014003, 0.309492276906572, 0.284432700242046,     0.415972769557452, 0.287005646014808, 0.370198317494659,     0.306067969315977, 0.366630998522083, 0.381449170776328,     0.346302710457366, 0.338892629495535, 0.349402909034886,     0.41321188404385, 0.27562864805546, 0.445113179361851, 0.354100140445193,     0.374742531193321, 0.314721099475238, 0.319275879884923,     0.468605025148932, 0.275168852234961, 0.440176297565083,     0.411838281203822, 0.420318168924518, 0.326116538421565,     0.492597489183583, 0.284993683226818, 0.351322719664274,     0.539604573374858, 0.518048239226765, 0.279226054558558,     0.386531523891434, 0.31119174484913, 0.254316215754273, 0.370891973560452,     0.287096639297258, 0.43397214164055, 0.40967588227666, 0.368409025913358,     0.384570337891502, 0.461683868547648, 0.465779320415054,     0.327538007678787, 0.35947489210124, 0.314346006805577, 0.298921789471833,     0.343076229916464, 0.391141919780731, 0.374803585046327,     0.270290182841048, 0.354621175981284, 0.272103890379817,     0.411476903802006, 0.331027770430139, 1, 0.511383525745394,     0.463594204462985, 0.328988867318923, 0.265926626823283,     0.298789524181184, 0.30240207044545, 0.474704140753685, 0.572374958215893,     0.193448245474484, 0.25827940856627, 0.379611884448205, 0.368581834831077,     0.370773311634279, 0.359824209439855, 0.35526717338933, 0.35988933780256,     0.367869727446468, 0.30506819259311, 0.476778397448414, 0.33667809035955,     0.452746059578913, 0.31974595182486, 0.253901843695459, 0.277352792227714,     0.280469069298394, 0.253690566459724, 0.400370153497853,     0.330815352449112, 0.438847454267895, 0.446052174130999,     0.505110718637475, 0.300107449655193, 0.235661193078848,     0.350133275717923, 0.281892850634102, 0.282901776532826,     0.354222701561, 0.371905516758958, 0.436337327021913, 0.253441521703603,     0.34952770127409, 0.447988088318429, 0.349332198792821, 0.221676504499138,     0.440748039178, 0.411200592162665, 0.314117320859563, 0.377215273825263,     0.443228959113693, 0.5292214641278, 0.415428441260639, 0.479311593664136,     0.525194670105282, 0.340375451986088, 0.394786428129171,     0.483045153606992, 0.238889943152848, 0.268093331892879,     0.310478303127039, 0.458548177770461, 0.273718396504909,     0.522119258004252, 0.522371110891469, 0.37156698352464, 0.331122724570433,     0.308354611891084, 0.443269072609031, 0.304497227437223,     0.356186201408988, 0.246672946807969, 0.399374375303164,     0.490563178979969, 0.451499745317075, 0.237142321479929,     0.415168700740002, 0.415948305269755, 0.380362040942608,     0.438256273553845, 0.441017481013547, 0.511383525745394,     1, 0.407507617583966, 0.49525355965405, 0.299439456424359,     0.342910929055457, 0.504194323318475, 0.464259907325015,     0.411119864095219, 0.283494277524802, 0.376462168325355,     0.37903353066091, 0.40527614238954, 0.436223631035291, 0.370165076237326,     0.305936304937063, 0.382266611233519, 0.447618295618557,     0.362679442487201, 0.438931600208343, 0.42125466872928, 0.493578465096747,     0.441088338067408, 0.404893913740347, 0.355067079123645,     0.326247799061532, 0.483720693850331, 0.389549195493502,     0.292114516838907, 0.546569699868135, 0.335032396837575,     0.377556807000924, 0.334204790136989, 0.302871432938645,     0.453517826502912, 0.433037689161269, 0.346085122043306,     0.306696792984607, 0.498064446444386, 0.349723690464106,     0.417150484194643, 0.360950035167167, 0.411833881407547,     0.345556465135609, 0.372131291354973, 0.505829332692671,     0.326671604912396, 0.352148408679815, 0.344771023498971,     0.367833925264066, 0.499276838661037, 0.41056805631188, 0.415891077915214,     0.517320655013493, 0.384493314080831, 0.362799547050396,     0.305426284050877, 0.327384009820995, 0.382255249902098,     0.429488136012502, 0.4228434844545, 0.471259982389482, 0.490705564191068,     0.477729525548367, 0.599411928330124, 0.490125455960313,     0.415949322132616, 0.527989063543064, 0.339189129306935,     0.361763505538409, 0.402220246440125, 0.375233923544586,     0.467207624157275, 0.468309643378041, 0.359633347527966,     0.402492537436455, 0.540154481265163, 0.375337907289887,     0.374271517584741, 0.322633078445593, 0.463594204462985,     0.407507617583966, 1, 0.386879485879339, 0.312460244069054,     0.424484867444712, 0.393986709295945, 0.373930173076563,     0.372925246770535, 0.296427838161706, 0.368721879556151,     0.296511098893387, 0.326692092018297, 0.381327352859154,     0.318454507403774, 0.313671106124219, 0.374845752891998,     0.440441571445526, 0.321938535120766, 0.404873365626289,     0.244844504718843, 0.398779252998756, 0.409829896404369,     0.268076565021159, 0.413486290677332, 0.309854860157672,     0.310225922002843, 0.307268654224817, 0.361823650117053,     0.311514817430568, 0.449339271234477, 0.362287707613588,     0.369124155237077, 0.298699935991411, 0.366641135171616,     0.344173146623062, 0.321502115598598, 0.266358187857144,     0.358139046847662, 0.525351108363716, 0.359639104257709,     0.405544840305818, 0.324491690085723, 0.337918470366693,     0.353506365557271, 0.406730458780709, 0.515673105980981,     0.303739686609177, 0.453631114158723, 0.576433079224612,     0.320483155476056, 0.325568246911218, 0.484552428308564,     0.460046811581744, 0.494771336521055, 0.385137346781347,     0.392366106995177, 0.367692186063551, 0.375555923689399,     0.414911450768174, 0.449882636460958, 0.381397586986246,     0.38240867687876, 0.507669744124442, 0.3976310401524, 0.43675020823548,     0.329619618167902, 0.426600988465129, 0.397390016665107,     0.494259313794908, 0.300237589591623, 0.356065884413039,     0.545300347008998, 0.365916054905633, 0.341797566356997,     0.479812725399419, 0.359642254760471, 0.406262803348289,     0.32496810466518, 0.530277608438971, 0.328988867318923, 0.49525355965405,     0.386879485879339, 1, 0.409836811051666, 0.369542457560192,     0.465621265962064, 0.344660965170937, 0.37492830166205, 0.400788151565311,     0.369715307737124, 0.360872618375835, 0.393485459208765,     0.352234956269643, 0.609707205943998, 0.304000912579353,     0.425566235810533, 0.392295786938097, 0.327188432984388,     0.441367535949358, 0.469696619385726, 0.328049960104713,     0.44596373398531, 0.363712488804337, 0.308258150121378, 0.353369126837725,     0.387760653666301, 0.272591587157388, 0.368590450471236,     0.457773299406744, 0.319798544919199, 0.260153273038179,     0.309369612898068, 0.442842163315647, 0.413614199743558,     0.521188938067236, 0.296008561975181, 0.323940515320982,     0.47070216152078, 0.299754468509879, 0.475062286457933, 0.392077290755861,     0.308552662257311, 0.253347797140881, 0.610643901771935,     0.474337402902826, 0.356234462587676, 0.587994597202802,     0.371141701249292, 0.370524028202691, 0.411036325245667,     0.324029774690403, 0.437807913708281, 0.462325024207163,     0.344877340754677, 0.362829145400469, 0.331445807088986,     0.396777960247772, 0.384925286269241, 0.353804960028931,     0.391340205622521, 0.416092140279557, 0.543073912100211,     0.367894829897913, 0.360183787587976, 0.352228855095833,     0.472416509917507, 0.575809644482948, 0.316777753751225,     0.442180042818918, 0.37599183886368, 0.3424120384053, 0.406478598189997,     0.469885696646875, 0.719832088254153, 0.302173184331479,     0.404116226737222, 0.304000497050391, 0.330630087524404,     0.268430689504521, 0.265926626823283, 0.299439456424359,     0.312460244069054, 0.409836811051666, 1, 0.338569070801897,     0.379010976481829, 0.344868435167714, 0.279463340037408,     0.406908943883754, 0.443876887960752, 0.358954724291915,     0.518883458885531, 0.260366217182467, 0.405336334306162,     0.39876500224612, 0.417879091936243, 0.320948074511229, 0.401817132626858,     0.325824169498909, 0.419235083368561, 0.322095435952688,     0.367102266450033, 0.531356033502905, 0.460025494093814,     0.428563336344988, 0.319682996433772, 0.443007301861903,     0.405495713603829, 0.334440787765778, 0.287378764296922,     0.383445757336681, 0.334632401085115, 0.405894247240108,     0.33572203830314, 0.385666262630182, 0.482976180776976, 0.528114015812326,     0.382602450353593, 0.401253657086464, 0.319473182626991,     0.351843142228657, 0.463412595200713, 0.412285027826057,     0.548987208681495, 0.35617250331797, 0.430963008240442, 0.477887501791495,     0.276475955255443, 0.303756225998486, 0.331214652657574,     0.357974346074065, 0.428924886745896, 0.33661960355041, 0.282812363841115,     0.296417104842061, 0.483779159602507, 0.403128822827149,     0.464241210011649, 0.321286824867829, 0.315196923804381,     0.304445037002189, 0.361569524748941, 0.327393795957064,     0.322771525787435, 0.284364617314733, 0.285223235838423,     0.259292975563137, 0.462010422103298, 0.327058275675807,     0.376360417974815, 0.411067896230931, 0.328852167279886,     0.379114495838251, 0.395504786748987, 0.401204914330021,     0.326599352729205, 0.366110729410289, 0.434973242247283,     0.402344669678313, 0.298789524181184, 0.342910929055457,     0.424484867444712, 0.369542457560192, 0.338569070801897,     1, 0.37680409945663, 0.395675547383487, 0.308390985656766,     0.486667455878216, 0.458803271931605, 0.216613170499336,     0.402680716193566, 0.340785200792473, 0.274711507244211,     0.313948520887422, 0.356451985515999, 0.368803646952245,     0.557996518311034, 0.439188976284342, 0.344609593876826,     0.335115093002925, 0.42495220115758, 0.500999549330243, 0.482044786769002,     0.262661829885391, 0.321901615277448, 0.316904479626278,     0.454752179163213, 0.350510700406055, 0.392373863626272,     0.268975204925227, 0.310746162238569, 0.228116143267427,     0.345399045518546, 0.38289259240638, 0.341030709725559, 0.457909936054477,     0.342362518757933, 0.407672109929216, 0.350184090386249,     0.389587749152396, 0.325416016668271, 0.429815867345687,     0.369677780407956, 0.404071703849155, 0.329855464276744,     0.320369830841351, 0.415030881394498, 0.345770508586537,     0.225101337995788, 0.319399355273752, 0.33546904468916, 0.317951716373332,     0.435552988213723, 0.375411232875351, 0.414707515817254,     0.594254451492258, 0.47811085955349, 0.47001953219957, 0.31023912344604,     0.350759772396658, 0.243831326057958, 0.355691498556481,     0.369064419792001, 0.397897316315452, 0.507452069412368,     0.481907670512669, 0.41430915657529, 0.437084003159565, 0.349760567961165,     0.276425603903831, 0.343839552309318, 0.311487083056878,     0.356749943090539, 0.374613742849185, 0.277497767424736,     0.378140590733028, 0.376305931460566, 0.300825877430602,     0.30240207044545, 0.504194323318475, 0.393986709295945, 0.465621265962064,     0.379010976481829, 0.37680409945663, 1, 0.311856192257752,     0.284272973416571, 0.478312056300117, 0.341380860007386,     0.390486082459881, 0.363267482828654, 0.38122842672745, 0.405498350203323,     0.274465773883652, 0.355166669336562, 0.360063807031317,     0.367643195798699, 0.275430668687151, 0.391483259680948,     0.368011557645588, 0.439662093051215, 0.370404470752825,     0.313663801088687, 0.381050230201674, 0.463972158401048,     0.226876878218621, 0.252613556343918, 0.340228164257098,     0.295864442876575, 0.239509829167427, 0.412134736050528,     0.397527243889061, 0.418412334354589, 0.38744781232155, 0.294980593551686,     0.222333814907404, 0.388588955199703, 0.336624389709106,     0.570025946575476, 0.296831875970954, 0.259104396189838,     0.343346508613634, 0.512328867437681, 0.3597913246364, 0.397416949494448,     0.360667695739485, 0.376541589052998, 0.34101872822172, 0.402976772774062,     0.323072705905642, 0.401935036559923, 0.385136253787169,     0.289803926832722, 0.275141932380817, 0.304654627391929,     0.404667900326529, 0.355785822830235, 0.474273552380606,     0.353546998511795, 0.548832474979106, 0.372792011773145,     0.490638867641417, 0.445146477321064, 0.395333416266961,     0.420636857737076, 0.480185106308731, 0.468151064759586,     0.334636224924518, 0.454724091668981, 0.375708137864692,     0.373230260428356, 0.568889814735508, 0.478442701085163,     0.373660779319315, 0.408886938895261, 0.376182984090773,     0.275732873058557, 0.511993824834656, 0.474704140753685,     0.464259907325015, 0.373930173076563, 0.344660965170937,     0.344868435167714, 0.395675547383487, 0.311856192257752,     1, 0.319488907034463, 0.326018908026281, 0.284749985115721,     0.385965700929329, 0.337624150587629, 0.597756820062762,     0.412389670856133, 0.393550188849423, 0.478092423494988,     0.562740693527066, 0.459658691997625, 0.374257142208551,     0.393139685400079, 0.373543533110253, 0.333349052910852,     0.375606437251128, 0.335338578527259, 0.332116080379577,     0.404797116415417, 0.491513636962021, 0.275123877732953,     0.392681708662176, 0.232706483952263, 0.527541454516535,     0.355634040670056, 0.25589926831072, 0.347870809245576, 0.381460244525696,     0.375868315855152, 0.428297378910694, 0.480983236304231,     0.437622646382516, 0.348112956523377, 0.278189123852046,     0.47657370289571, 0.586520323109763, 0.233118881565033, 0.481554528315806,     0.411026900473635, 0.376798441031134, 0.360538913350434,     0.463999447780785, 0.502385002714462, 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#> 
#> $kernDKpls2DR_mod
#> Gaussian Radial Basis kernel function. 
#>  Hyperparameter : sigma =  0.0122566708271971 
#> 
(cox_DKpls2DR_fit=coxDKpls2DR(~X_train_micro,Y_train_micro,C_train_micro,ncomp=6,
validation="CV",allres=TRUE))
#> Error in model.matrix(mt0, mf0, , contrasts.arg = contrasts.arg): argument "contrasts.arg" is missing, with no default
(cox_DKpls2DR_fit=coxDKpls2DR(~.,Y_train_micro,C_train_micro,ncomp=6,validation="CV",
allres=TRUE,dataXplan=X_train_micro_df))
#> Error in model.matrix(mt0, mf0, , contrasts.arg = contrasts.arg): argument "contrasts.arg" is missing, with no default


rm(X_train_micro,Y_train_micro,C_train_micro,cox_DKpls2DR_fit)